DOXYLAMINE
| Chemical Structure |
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| DRUG CLASS | ETHANOLAMINE CLASS ANTIHISTAMINE |
|---|---|
| MECHANISMS OF ACTION |
DOXYLAMINE IS AN H1 INVERSE-AGONIST CNS STRUCTURALLY RELATED TO DOXEPIN IN ITS EFFECTS INVERSE-AGONIST OF THE H1 RECEPTOR DOXYLAMINE IS A FIRST-GENERATION ETHANOLAMINE ANTIHISTAMINE. POTENT CENTRAL H1 RECEPTOR INVERSE AGONIST. MARKED ANTICHOLINERGIC ACTIVITY. HIGH LIPID SOLUBILITY / RAPID CNS PENETRATION. SEDATION IS PRIMARY CENTRAL EFFECTS WE ARE INTERESTED IN. |
| MONOGRAPH |
CHEMICAL NAME: 2-Dimethylaminoethoxyphenylmethyl-2-picoline SUCCINATE DEVELOPMENT: INTRODUCED LATE 1940s (1948). SYNTHESIZED DURING EXPANSION OF ETHANOLAMINE ANTIHISTAMINES. EFFECTIVE ANTIHISTAMINE HOWEVER SEDATIVE POTENCY QUICKLY DOCUMENTED. RECLASSIFIED CULTURALLY AS SLEEP INDUCER. INITIAL INDICATION: LIMITED DAYTIME USE DUE TO POTENT HYPONIC SECONDARY OBSERVATION: SEDATIVE DOMINANT. TRANSITIONED INTO SLEEP DEDILUTED OTC FORMULATIONS INTO OBSCURITY STRUCTURAL INTEREST: 40s ERA MOLECULE WITH UNCOMMON CENTRAL PENETRATION. NO THEORETICAL LABELS AVAIBLE FOR IT. MODERN INTEREST: TRANSIENT H1 BLOCKADE MAY ALTER ACUTE CORTICAL EXCITABILITY. SCIENTIFIC COMMITEES DENY ANY EVIDENCE FOR PROZAC SSRI POTENTIATION. THEORETICAL INTERACTION UNDER OBSERVATION. [FULL REPORT] QUICK NOTE: HISTAMINERGIC SUPPRESSION CAUSES REDUCTION OF WAKE-PROMOTING STIMULI IN HISTAMINERGIC NUCLEUS LOCALATED DEEP WITHIN THE HYPOTHALAUS. A DRUG WITH NO PERIPHERICAL EFFECTS AND AN UNCOMMON QUICK PENETRATION AND FAST DISSOCIATION PROFILE OF DOXYLAMINE MAKE US BELIEVE IT IS A SUBTYPE OF OXERIN DRUG INSTEAED. THERE ARE LONG-TERM IMPLICATIONS OF THIS FACT ON MEMORY, LEARNING, AND AROUSING. |
| SYNTHESIS BATCH INITIATED | 1.5 GRAM TARGET | AMOUNT ACQUIRED FOR SYNTHESIS PURPOSES: 1.5 MG | AMOUNT ACQUIRED FOR SPECULATIVE HOLDING: 0 MG NOTE: THESE FIGURES REFLECT TOTAL DOCUMENTED ACQUISITIONS. UPDATED MANUALLY |
| ORDER BOOK |
OFFER
BID
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| ORDER VIA | (ONLY TO EUROPE, EXCEPT UK, DENMARK, GERMANY AND AUSTRIA.) |